BACKUP BACKUP BACKUP Backing up your work on a regular basis gives you the security of knowing that even if you do toss something before its time - you can retrieve it. This makes maintenance a worry free activity. You will be amazed at how much you never refer to again.
Hard drives fail more often than any other component on a typical computer. When a hard drive fails it is normally impossible to recover any data from it without spending a small fortune at a data recovery service. Therefore, if you have any data on your computer that is at all valuable to you, having a functional backup system in-place is absolutely essential. If you already have a functional backup system in-place, make sure it's actually working! You should backup as often as you create data that you would not want to loose. Also, if your backup procedure is automated don't assume it is working! Check it frequently.
In the realm of software applications, there has been a shift towards online applications that don't require a physical application (and relevant data) to be stored on your hard disk. These applications are invaluable to most users - not only because you can access your data from anywhere with an internet connection, but because you no longer have to worry about backing up that data. The online application gives you that piece of mind because it handles backups for you. For example, using KeepMore.net will allow you to access your bookkeeping (and other business) data from anywhere, and backs it up every single night. That way, wherever you go - your data is there with you.